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toxicology
I. introduction
1. Health hazards
II. Gene mutation
1. Microbial Test in Vitro
2. Insects
3. Mammalian Cells in Culture
III. Chromosomal Effects
1. Cytogenetic Studies with Mammalian Cells (유전독성시험)
2. DNA repair and recombination
IV. Evaluation
1. Selection of Test S
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Toxicology
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-toxicology in Drug Discovery and Development. International Journal of Pharmacology, 9: 176-181.https://doi.org/10.3923/ijp.2013.176.181
Valerio, L.G. In silicotoxicology models and databases as FDA Critical Path Initiative toolkits. Hum Genomics 5, 200 (2011). https://doi.org/10.1186/1479-7364-5-3
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ree radical을 형성.
ex) benzo(a)pyrene(BaP)은 benzo(a)pyrene 7,8-diol 9,10-epoxide(BPDE), ROS, Bap radical cation을 생성
- antioidants : antioxidant vitamins, curcumin, isoflavonoids, resveratrol(포도주에 존재), plant polysaccharides 체내 항산화제가 부족하므로 이런 항산화제를 먹어
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식품독성학 ) in silico toxicology 또는 In silico ADME study에 대한 동향 조사
목차
1. 연구동향
2. 출처 및 참고문헌
1. 연구동향
최근 식품 독성학 분야에서는 in silico toxicology와 in silico ADME(흡수, 분포, 대사, 배출) 연구가 급속히 발전하고
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